has mode of inheritance has causal genotype has causal or contributing genetic variation has causal molecular phenotype Autosomal Dominant Structural Hemoglobinopathy HBB, GLU6VAL HBB, GLU121LYS Hemoglobin S-Oman Hemoglobin Genotype A/S-Oman Sickle Cell Disease A/S-Oman None SCDO (Jade Hotchkiss) Request inclusion into relevant ontology Sickle cell disease caused by two mutations in the same beta globin allele, specifically the sickle cell mutation (beta6 Glu > Val) and the hemoglobin O-Arab mutation (beta121 Glu > Lys). The other beta globin allele produces normal beta globin chains. Dominant Sickle Cell Disease