has mode of inheritance has causal or contributing genetic variation has causal molecular phenotype Autosomal Recessive Structural Hemoglobinopathy HBB, GLU6VAL HBB, ASP73ASN Hemoglobin C-Harlem Hemoglobin C-Harlem Disease SCDO (Jade Hotchkiss) None Request inclusion into relevant ontology A clinically severe form of sickle cell disease resulting when a person is homozygous for Hemoglobin C-Harlem.