Abnormal Erythrocyte Physiology Increased Red Cell Osmotic Fragility An increase in red blood cell sensitivity to change in osmotic pressure. More specifically, the degree or proportion of hemolysis that occurs when a sample of red blood cells are subjected to osmotic stress by being placed in a hypotonic solution. HP:0005502 Increased Red Cell Fragility What is normal osmotic fragility? Perhaps this can be included in the description. Suggest update to description in the HPO. Currently no description given. Include "Osmotic Fragility Test" in an appropriate location below "Diagnostics Tools" and link to this term. Suggest update to description. SCDO (Jade Hotchkiss) Increased Erythrocyte Osmotic Fragility