polypeptide_motif motif SO:0001067 polypeptide motif Range. BS:00032 sequence A sequence motif is a short (up to 20 amino acids) region of biological interest. Such motifs, although they are too short to constitute functional domains, share sequence similarities and are conserved in different proteins. They display a common function (protein-binding, subcellular location etc.). polypeptide_conserved_region