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    <!-- http://purl.obolibrary.org/obo/SO_0001589 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/SO_0001589">
        <rdfs:label>frameshift_variant</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/SO_0001818"/>
        <oboInOwl:hasDbXref>http://snpeff.sourceforge.net/SnpEff_manual.html</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>snpEff:FRAME_SHIFT</oboInOwl:hasExactSynonym>
        <rdfs:comment>EBI term:Frameshift variations - In coding sequence, resulting in a frameshift.</rdfs:comment>
        <oboInOwl:hasRelatedSynonym>Seattleseq:frameshift-near-splice</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasOBONamespace>sequence</oboInOwl:hasOBONamespace>
        <oboInOwl:hasExactSynonym>Seattleseq:frameshift</oboInOwl:hasExactSynonym>
        <oboInOwl:hasRelatedSynonym>ANNOVAR:frameshift block substitution</oboInOwl:hasRelatedSynonym>
        <oboInOwl:created_by>kareneilbeck</oboInOwl:created_by>
        <oboInOwl:hasExactSynonym>VAAST:frameshift_variant</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>http:www.ensembl.org/info/genome/variation/predicted_data.html#consequences</oboInOwl:hasDbXref>
        <oboInOwl:hasNarrowSynonym>VAT:insertionFS</oboInOwl:hasNarrowSynonym>
        <oboInOwl:creation_date>2010-03-22T02:40:19Z</oboInOwl:creation_date>
        <oboInOwl:hasExactSynonym>frameshift_coding</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>VEP:frameshift_variant</oboInOwl:hasExactSynonym>
        <oboInOwl:id>SO:0001589</oboInOwl:id>
        <oboInOwl:hasExactSynonym>Jannovar:frameshift_variant</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>frameshift variant</oboInOwl:hasExactSynonym>
        <oboInOwl:hasNarrowSynonym>VAT:deletionFS</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasExactSynonym>frameshift_</oboInOwl:hasExactSynonym>
        <oboInOwl:hasRelatedSynonym>ANNOVAR:frameshift substitution</oboInOwl:hasRelatedSynonym>
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        <ns3:IAO_0000115>A sequence variant which causes a disruption of the translational reading frame, because the number of nucleotides inserted or deleted is not a multiple of three.</ns3:IAO_0000115>
        <oboInOwl:hasDbXref>loinc:LA6694-9</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>http://snp.gs.washington.edu/SeattleSeqAnnotation137/HelpHowToUse.jsp</oboInOwl:hasDbXref>
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    <!-- http://purl.obolibrary.org/obo/SO_0001818 -->

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        <rdfs:label>protein_altering_variant</rdfs:label>
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