KEN_box KEN box A conserved polypeptide motif that can be recognized by FZR/Cdh1-activated anaphase-promoting complex/cyclosome (APC/C) and targets a protein for ubiquitination and subsequent degradation by the APC/C. The consensus sequence is KENXXXN. 2011-06-17T12:24:14Z kareneilbeck sequence SO:0001807 polypeptide_conserved_motif