derives_from methylation_guide_snoRNA_primary_transcript C_D_box_snoRNA methylation_guide_snoRNA A snoRNA that specifies the site of 2'-O-ribose methylation in an RNA molecule by base pairing with a short sequence around the target residue. SO:0005841 methylation guide snoRNA sequence Has RNA 2'-O-ribose methylation guide activity (GO:0030561).