is about has_specified_input is_specified_output_of executes planned process selection criterion effect size estimate z-score strictly standardized mean difference hit selection Orlaith Burke AGB, PRS Alejandra Gonzalez-Beltran Philippe Rocca-Serra adapted from: http://en.wikipedia.org/wiki/SSMD adapted from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789971/ hit selection is a planned process which in screening processes such as high-throughput screening, lead to the identification of perturbing agent which cause the typical signal generated by a standardized assay to significantly differ from the negative control. The selection hitself results from meeting or exceeding selection threshold (for instance 6 sigma from the mean or SSMD value beyond 5 when compared to positive controls or below -5 when compared to negative controls between group comparison statistical test p-value pending final vetting