testing margin equivalence margin Brian Alper, Harold Lehmann, Ken Wilkins, Joanne Dehnbostel, Homa Keshavarz An equivalence goal is defined as a study goal with the intent to compare two or more interventions or exposures and to determine that the absolute value of any difference in effects is smaller than a prespecified value representing a meaningful difference. Philippe Rocca-Serra adapted from SEVCO. A hypothesis testing margin used in a study with an equivalence goal. The equivalence margin is a predefined threshold that specifies how large a difference between two treatments (or groups) can be and still be considered practically the same. It defines the range of differences that are not clinically or practically meaningful. ready for release