has specified data input has specified data output implements has format specification Image data item CEL binary format Harshlight http://bioconductor.org/packages/2.4/bioc/html/Harshlight.html The package is used to detect extended, diffuse and compact blemishes on microarray chips. Harshlight automatically marks the areas in a collection of chips (affybatch objects) and a corrected AffyBatch object is returned, in which the defected areas are substituted with NAs or the median of the values of the same probe in the other chips in the collection. The new version handle the substitue value as whole matrix to solve the memory problem. Nandini Badarinarayan RMA 'MAS5' R software PostScript