has specified data input has specified data output implements PLIER (Probe Logarithmic Error Intensity Estimate) method Gene expression dataset plier The PLIER (Probe Logarithmic Error Intensity Estimate) method produces an improved signal by accounting for experimentally observed patterns in probe behavior and handling error at the appropriately at low and high signal values. http://bioconductor.org/packages/2.4/bioc/html/plier.html Nandini Badarinarayan R software