has specified data input has specified data output is specified data input of implements has format specification is published by R data frame Bootstrap Global test Graph plot safe 3 Nandini Badarinarayan SAFE is a resampling-based method for testing functional categories is gene expression experiments. SAFE can be applied to 2-sample and multi-class comparisons, or simple linear regressions. Other experimental designs can also be accommodated through user-defined functions. http://bioconductor.org/packages/2.4/bioc/html/safe.html 't-test' ALL/AML data set 'ANOVA' BioConductor Software R software Text data set Bioconductor