Zinc-coordinating DNA-binding domains C3H zinc finger factors CLASSLINK:http\://www.edgar-wingender.de/class 2.8.html Class Class description: These factors comprise a putative zinc finger motif with the signature C------C-----C---H. DNA-binding has been proven only for three proteins of this class, ZC3H8 (2.8.1.0.1), of which closely related proteins have been included for similarity, ZGPAT (2.8.2.0.1), with no close relatives found, and RC3H2 (2.8.4.0.1). Most, if not all, other proteins of this class appear to be RNA-binders and be involved more likely in splicing rather than transcriptional regulation.