has role phosphosphingolipid sphingosine-1-phosphate IMR:0100179 S1P Sphingolipid mediators, such as sphingosine 1-phosphate (S1P), ceramide, and sphingosine are derived by the enzymatic breakdown of sphingomyelin, an abundant membrane phospholipid. S1P is an evolutionarily conserved bioactive lipid mediator with potent effects on multiple organ systems. A phosphosphingolipid that consists of sphingosine having a phospho group attached at position 1 second messenger lipid mediator