has role has attribute value has attribute xenobiotic clozapine 8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia. Beilstein:0764984 CAS:5786-21-0 CHEBI:3766 Clozapin Clozapine DrugBank:DB00363 Drug_Central:722 PMID:18690109 PMID:18766167 PMID:20825390 PMID:24219174 Reaxys:764984 clozapina clozapine clozapinum adrenergic antagonist histamine antagonist serotonergic antagonist dopaminergic antagonist muscarinic antagonist organic molecular entity second generation antipsychotic GABA antagonist EC 3.4.21.26 (prolyl oligopeptidase) inhibitor environmental contaminant drug liver toxicity Most-DILI-Concern