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    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
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    <!-- http://purl.obolibrary.org/obo/RO_0000087 -->

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        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">has role</rdfs:label>
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    <!-- http://purl.obolibrary.org/obo/TXPO_0000826 -->

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    <!-- http://purl.obolibrary.org/obo/TXPO_0001862 -->

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    <!-- http://purl.obolibrary.org/obo/CHEBI_22333 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_22333">
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">alkylating agent</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_35610 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35610">
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">antineoplastic agent</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_4868 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_4868">
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">estramustine</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_50860"/>
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                                <onProperty rdf:resource="http://purl.obolibrary.org/obo/TXPO_0000826"/>
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                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35610"/>
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                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_22333"/>
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                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_66987"/>
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        <oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">(17beta)-17-hydroxyestra-1(10),2,4-trien-3-yl bis(2-chloroethyl)carbamate</oboInOwl:hasExactSynonym>
        <oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">17beta-Estradiol 3-(bis(2-chloroethyl)carbamate)</oboInOwl:hasRelatedSynonym>
        <ns4:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A carbamate ester obtained by the formal condensation of the hydroxy group of 17beta-estradiol with the carboxy group of bis(2-chloroethyl)carbamic acid.</ns4:IAO_0000115>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Beilstein:5637599</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CAS:2998-57-4</oboInOwl:hasDbXref>
        <oboInOwl:id rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CHEBI:4868</oboInOwl:id>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DrugBank:DB01196</oboInOwl:hasDbXref>
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        <oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Estradiol 3-(N,N-bis(2-chloroethyl)carbamate)</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Estramustine</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">LIPID_MAPS_instance:LMST02010038</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:11131983</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:15762353</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:7638085</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reaxys:5637599</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">estramustina</oboInOwl:hasRelatedSynonym>
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    <!-- http://purl.obolibrary.org/obo/CHEBI_50860 -->

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        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">organic molecular entity</rdfs:label>
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    <!-- http://purl.obolibrary.org/obo/CHEBI_66987 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_66987">
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">radiation protective agent</rdfs:label>
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    <!-- http://purl.obolibrary.org/obo/TXPO_0004321 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/TXPO_0004321">
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">drug liver toxicity</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/TXPO_0004323 -->

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        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Most-DILI-Concern</rdfs:label>
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