has role has attribute value has attribute Hedgehog signaling pathway inhibitor P450 inhibitor organic molecular entity itraconazole 2-(butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one An N-arylpiperazine that is cis-ketoconazole in which the imidazol-1-yl group is replaced by a 1,2,4-triazol-1-yl group and in which the actyl group attached to the piperazine moiety is replaced by a p-[(+-)1-sec-butyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]phenyl group. A potent P-glycoprotein and CYP3A4 inhibitor, it is used as an antifungal drug for the treatment of various fungal infections, including aspergillosis, blastomycosis, candidiasis, chromoblastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, and sporotrichosis. CAS:84625-61-6 CHEBI:6076 DrugBank:DB01167 Itraconazole Itrizole (TN) Oriconazole PMID:11219548 PMID:11403818 PMID:11422002 PMID:15521894 PMID:19025521 PMID:20400651 PMID:25326091 Sporanox (TN) itraconazole EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor drug liver toxicity Most-DILI-Concern