has role has attribute value has attribute EC 2.1.1.6 (catechol O-methyltransferase) inhibitor antiparkinson drug organic molecular entity tolcapone (3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone 3,4-Dihydroxy-4'-methyl-5-nitrobenzophenone 3,4-dihydroxy-4'-methyl-5-nitrobenzophenone 3,4-dihydroxy-5-nitro-4'-methylbenzophenone 4'-methyl-3,4-dihydroxy-5-nitrobenzophenone Benzophenone substituted on one of the phenyl rings at C-3 and C-4 by hydroxy groups and at C-5 by a nitro group, and on the other phenyl ring by a methyl group at C-4. It is an inhibitor of catechol O-methyltransferase. CHEBI:63630 DrugBank:DB00323 Drug_Central:2697 LINCS:LSM-5282 PMID:20381177 PMID:20502133 PMID:21521027 PMID:22136163 Reaxys:8151577 tolcapone drug liver toxicity Most-DILI-Concern