has role has attribute value has attribute antiparasitic agent non-steroidal anti-inflammatory drug antineoplastic agent immunosuppressive agent EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor tyrosine kinase inhibitor prodrug organic molecular entity hepatotoxic agent leflunomide 5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide 5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide. Arava Beilstein:4323174 CAS:75706-12-6 CHEBI:6402 DrugBank:DB01097 Drug_Central:1552 LINCS:LSM-3771 Leflunomide PMID:10515382 PMID:10702725 PMID:10890256 PMID:11043056 PMID:11053058 PMID:11067959 PMID:11271257 PMID:11333342 PMID:11340750 PMID:11391470 PMID:11475244 PMID:11522581 PMID:11707749 PMID:11718154 PMID:11876141 PMID:11884931 PMID:11994686 PMID:12017890 PMID:12074690 PMID:12833393 PMID:14622739 PMID:15030575 PMID:15127968 PMID:15127974 PMID:15188371 PMID:15214907 PMID:15385935 PMID:15489872 PMID:15537652 PMID:15652966 PMID:15665760 PMID:15789891 PMID:15899055 PMID:15934905 PMID:16106593 PMID:16142756 PMID:16202258 PMID:16284916 PMID:16638062 PMID:16638420 PMID:16645972 PMID:16688677 PMID:16769661 PMID:16778342 PMID:17366662 PMID:17604599 PMID:17646975 PMID:17854740 PMID:18034546 PMID:18173611 PMID:18413415 PMID:18496682 PMID:18663553 PMID:18688040 PMID:19169882 PMID:19190124 PMID:19344337 PMID:19581389 PMID:19715969 PMID:19751817 PMID:19770782 PMID:7496341 PMID:7676489 PMID:8610393 PMID:9075844 PMID:9123314 PMID:9625011 PMID:9777697 Reaxys:4323174 alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide leflunomida leflunomide leflunomidum EC 1.3.98.1 [dihydroorotate oxidase (fumarate)] inhibitor pyrimidine synthesis inhibitor drug liver toxicity Most-DILI-Concern