has role has attribute value has attribute non-steroidal anti-inflammatory drug non-narcotic analgesic antipyretic antipsoriatic organic molecular entity hepatotoxic agent nephrotoxin protein kinase C agonist EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor benoxaprofen (+-)-benoxaprofen (1)-2-(4-Chlorophenyl)benzoxazole-5-propionic acid 2-(4-Chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid 2-(4-chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid 2-(p-chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid 2-[2-(4-chlorophenyl)-1,3-benzoxazol-5-yl]propanoic acid A monocarboxylic acid that is propionic acid substituted at position 2 by a 2-(4-chlorophenyl)-1,3-benzoxazol-5-yl group. It was used as a non-steroidal anti-inflammatory drug until 1982 when it was withdrawn from the market due to adverse side-effects including liver necrosis, photosensitivity, and carcinogenicity in animals. CAS:51234-28-7 CHEBI:76114 DL-benoxaprofen DrugBank:DB04812 Drug_Central:311 Lilly 90459 PMID:19439485 PMID:19773537 PMID:21128314 PMID:22514582 PMID:23250699 PMID:2413686 PMID:2833969 PMID:2947294 PMID:3981515 PMID:6407402 PMID:6526401 PMID:6645654 PMID:6813936 PMID:6993669 PMID:6993670 PMID:6993671 PMID:6993672 PMID:7044799 PMID:7044801 PMID:7084283 PMID:7084287 PMID:7221526 Reaxys:1085080 benoxaprofen benoxaprofene benoxaprofeno benoxaprofenum drug liver toxicity Most-DILI-Concern