has role has attribute value has attribute organic molecular entity EC 3.1.1.3 (triacylglycerol lipase) inhibitor EC 2.3.1.85 (fatty acid synthase) inhibitor anti-obesity agent bacterial metabolite orlistat (-)-tetrahydrolipostatin (2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl N-formyl-L-leucinate (2S)-2-formamido-4-methylpentanoic acid [(2S)-1-[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]tridecan-2-yl] ester A carboxylic ester resulting from the formal condensation of the carboxy group of N-formyl-L-leucine with the hydroxy group of (3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one. A pancreatic lipase inhibitor, it is used as an anti-obesity drug. Alli CAS:96829-58-2 CHEBI:94686 Drug_Central:1996 LINCS:LSM-5724 N-formyl-L-leucine (1S)-1-{[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl}dodecyl ester PMID:27793869 PMID:28097013 PMID:28191026 PMID:28260907 PMID:28387458 PMID:28559211 PMID:28588183 PMID:28624425 Reaxys:3658031 Ro-18-0647 Xenical orlipastat orlistat orlistatum drug liver toxicity Most-DILI-Concern