has role Mdm2 (mol) MDM2 (canonical)[Glutathione depletion] This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013] http://www.genecards.org/cgi-bin/carddisp.pl?gene=MDM2 NCBI-Rat-GeneID:314856 NCBI-Human-GeneID:4193 NCBI-Mouse-GeneID:17246 glutathione depletion dependent molecule (canonical) p53 inhibitor