has part has participant has result has context PERK signaling to eIF2a [ER stress - translation attenuation] A process in which a signal to eIF2a is transduced by PERK. This process is dependent on the translation attenuation and can constitute the course of ER stress. ER stress dependent process PERK - signaling factor (canonical)[ER stress - translation attenuation] PERK signaling to eIF2a [ER stress] changing activity of eIF2a by PERK [ER stress - translation attenuation] PERK activation [ER stress - translation attenuation] endoplasmic reticulum stress [toxic course] regulation of translation by eIF2a [ER stress - translation attenuation]