occurs in has participant has result has context has finding homo sapiens rodentia eosinophilic granular degeneration [toxic course] peroxisomal proliferation in hepatocyte peroxisomal proliferation in hepatocyte [Eosinophilic granular degeneration] Humanized mice (ie, PPARalpha-null mice transfected with human PPAR alpha) also fail to respond with hepatocellular and peroxisomal proliferation to fibrates, indicating that the human receptor cannot signal for proliferation. Humans do not respond with hepatocellular and peroxisomal proliferation to fibrates and express PPARalpha at low levels and often in nonfunctional forms. Casarett & Doull's Toxicology: The Basic Science of Poisons, Eighth Edition Peroxisomal proliferation in hepatocyte is a subtype of hepatocyte organelle proliferation: A process that becomes larger in the number of peroxisome in hepatocyte(s). This entity is a specific course-dependent process. This process can constitute the course of Eosinogranular degeneration. increasing hepatocellular volume [Eosinophilic granular degeneration] Pex11a (mouse)[Eosinophilic granular degeneration] eosinophlic granular degeneration dependent process eosinophilic granular degeneration [Liver Pathological Findings] [eosinogranular degeneration (course) ]