has molecular reaction has result has context has agent PERK signaling to eIF2a [ER stress - translation attenuation] receiving abnormal protein signal by PERK [ER stress - translation attenuation] Receiving abnormal protein signal by PERK is a subtype of receiving signal: A process that recognizes another object and changes into an abnormal protein (e.g., misfolded protein, etc.) signal by PERK. This process is dependent on the translation attenuation and can constitute the course of ER stress. Dissociation of PERK:BIP Heterodimer [ER stress translation attenuation] ER stress dependent process endoplasmic reticulum stress [toxic course] PERK - signal sensor (canonical)[ER stress - translation attenuation] receiving abnormal protein signal by PERK [ER stress]