has role has output material entity electrophilic reagent biosynthetic process electrophiles formation A number of xenobiotics exert a toxic effect theough their metabolites. Electrophiles are molecules that contain an electron-deficient atom with a partial or full positive charge that can react by sharing electron pairs with electron rich atoms in nucleophiles. Electrophilic toxicants generally are detoxificated by conjugation of with the nucleophile, glutathione. This reaction can be facilitated by glutathione S-trasferases. Electrophiles formation is a subtype of biosynthetic process: A process that that generates electrophiles. Electrophile is a reagent that forms a bond to its reaction partner (the nucleophile) by accepting both bonding electrons from that reaction partner..