has part has core process toxic course glutathione depletion [toxic course] PMID:16500922 PMID:22995213 PMID:23856494 PMID:24287781 The totality of all processes through which glutathione depletion is realized. hyperfunction of antioxidant gene expression [Glutathione depletion] negative regulation of glycolytic process [Glutathione depletion] inflammasome activation [Glutathione depletion] NRF2 signaling (primitive) [Glutathione depletion] negative regulation of apoptotic process [Glutathione depletion] increasing drug metabolite [Glutathione depletion] compound accumulation in liver [Glutathione depletion] hyperfunction of drug metabolizing enzyme gene expression [Glutathione depletion] hyperfunction of cytochrome P450 gene expression [Glutathione depletion] hyperfunction of drug metabolism phase I by Cytochrome P450 [Glutathione depletion] cytochrome P450 activation [Glutathione depletion] NAPQI production [Glutathione depletion] increasing demand for glutathione conjugation [Glutathione depletion] JNK translocation from cytoplasm to mitochondria [Glutathione depletion] decreasing excretion quantity of the conjugates [Glutathione depletion] Glutathione conjugation (supply) - function demand imbalance [Glutathione depletion] NAPQI accumulation [Glutathione depletion] glutathione depletion [Glutathione depletion] glutathione biosynthetic process [Glutathione depletion] protein binding by NAPQI [Glutathione depletion] malfunctioning of mitochondrial ATP synthesis coupled electron transpor [Glutathione depletion] DNA damage [Glutathione depletion] increasing free radical [Glutathione depletion] lipoperoxidation [Glutathione depletion] increasing demand for response to mitochondrial oxidative stress [Glutathione depletion] mitochondrial dysfunction [Glutathione depletion] hypofunction of ATP biosynthesis [Glutathione depletion] cell death [Glutathione depletion] abnormality of membrane [Glutathione depletion] calcium ion homeostasis imbalance [Glutathione depletion] positive regulation of mitochondrial membrane permeability [Glutathione depletion] electrophiles formation [Glutathione depletion] hyperfunction of glutathione synthetic gene expression [Glutathione depletion] negative regulation of glutathione biosyntheric process [Glutathione depletion] glutathione synthetic gene expression [Glutathione depletion] cell survival [Glutathione depletion] dissociation of Nrf2-Keap1 complex [Glutathione depletion] activation of thioredoxin pathway [Glutathione depletion] hyperfunction of anti-oxidative stress [Glutathione depletion] p53 signaling (primitive) [Glutathione depletion] caspase signaling (primitive) [Glutathione depletion] apoptotic process [Glutathione depletion] increasing number of dead cells in liver [Glutathione depletion] liver dysfunction [Glutathione depletion] JNK signaling (primitive) [Glutathione depletion] regulation of cell cycle [Glutathione depletion] NADPH regeneration [Glutathione depletion] Keap1 inactivation [Glutathione depletion] Keap1 modification by electrophiles [Glutathione depletion] negative regulation of inflammatory response [Glutathione depletion] hyperfunction of glutathione conjugates excretion from hepatocyte [Glutathione depletion] hyperfunction of glutathione export from hepatocyte [Glutathione depletion] negative regulation of bile acid and bile salts export from the hepatocyte to bile tube [Glutathione depletion] cholestasis [Glutathione depletion] Bile acid accumulation in hepatocyte [Glutathione depletion] inflammatory response [Glutathione depletion] reactive oxygen species biosynthetic process [Glutathione depletion] increasing demand for response to oxidative stress [Glutathione depletion] increasing anti-oxidation demand [Glutathione depletion] oxidation-antioxidtion inbalance [Glutathione depletion] ROS accumulation [Glutathione depletion] hyperfunction of peroxisomal fatty acid beta-oxidation [Glutathione depletion] iron accumulation [Glutathione depletion] kupffer cell activation [Glutathione depletion] accumulation of ethanol in intestine [Glutathione depletion] LPS translocation from gut to liver [Glutathione depletion] inflammatory cytokine gene expression [Glutathione depletion] tumorigenesis [Glutathione depletion] hypofunction of glutathione conjugation [Glutathione depletion]