has part has result has context has pathway apoptotic process increasing number of dead cells in liver [ER stress] apoptotic process [ER stress] A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. This entity is a specific course-dependent process. This process can constitute the course of ER stress. ISBN:0123878179 ER stress dependent process endoplasmic reticulum stress [toxic course] BIM activation [ER stress - apoptosis - IRE1−TRAF2-JNK-Bcl2 pathway] caspase 12 signaling (primitive) [ER stress - apoptosis] caspase 4 signaling (primitive) [ER stress - apoptosis] caspase pathway [ER stress - apoptosis] caspase 9 signaling (primitive) [ER stress - apoptosis] caspase 3 signaling (primitive) [ER stress - apoptosis] release of cytochrome c from mitochondria [ER stress] BAK activation [ER stress] BAX activation [ER stress] apoptosome assembly [ER stress] Bax/Bak complex formation [ER stress]