has part has result has context apoptotic process cell ceath [cell death (toxic course)] membrane blebbing [Cell death] cell death (toxic course) apoptotic process [Cell death] A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. This entity is a specific course-dependent process. This process can constitute the course of Cell death. negative regulation of tumor cell proliferation [Cell death] negative regulation of autophagy [Cell death] apoptotic DNA fragmentation [Apoptosis]