regulation of Cxcl2 expression by TNF-alpha CXCL1 is one of the members of chemokines, which are small heparin-binding proteins that generally direct the movement of circulating leukocytes to sites of inflammation or injury. TNF-α stimulates CXCL1 release from human ECs through JNK-mediated CXCL1 mRNA expression and p38 MAPK- and PI-3K-mediated CXCL1 secretory processes. PMID:24487964 Regulation of Cxcl2 expression by TNF-alpha is a subtype of regulation of gene expression by TNF-alpha: A process that Any process that modulates the frequency, rate or extent of Cxcl2 expression by TNFalpha. TNFalpha->JNK->AP-1->CXCL1 mRNA expression TNFalpha->p38MAPK->PI3K->AKT->CXCL1 release from the cell membrane regulation of gene expression by TNF-alpha