observed in cytoplasm cytoplasmic alternation [Liver Pathological Findings] Changes in cytoplasm in the hepatocytes. Liver is responsible for drug metabolism; therefore these findings are most frequently observed results in drug safety studies. It shows various morphological images depending on the kind of chemical substance. Cytoplasmic alternation [Liver PathologicalFindings] is a type of finding observed in the liver. Lesions are observed as changes in cytoplasm based on pathological morphology. cytoplasmic change [Liver PathologicalFindings] pathological finding