has part toxic course mitochondrial dysfunction [Oxidative stress] increasing demand for response to oxidative stress [Oxidative stress] oxidation-antioxidtion inbalance [Oxidative stress] increasing free radical [Oxidative stress] apoptotic process [Oxidative stress] abnormality of membrane [Oxidative stress] lipoperoxidation [Oxidative stress] positive regulation of mitochondrial membrane permeability [Oxidative stress] calcium ion homeostasis imbalance [Oxidative stress] hypofunction of ATP biosynthesis [Oxidative stress] oxidative stress [toxic course] Generation of free radicals or depletion of free radical scavengers and other antioxidant defences such as glutathione -> generation of reactive oxyen metabolites ->damaging effects on cell The totality of all processes through which oxidative stress is realized. cell death [Oxidative stress] Inflammatory response [Oxidative stress] increasing number of dead cells in liver [Oxidative stress]