has part has core process dysfunction of calcium transport [Cell death] cellular damage [Cell death] cell death (toxic course) hypofunction of ATP biosynthesis [cell death] increase in intracellular calcium level [Cell death] ATP depletion [Cell death] leaking content from cell [Cell death] inflammatory cell infiltration [Cell death] ischemia [Cell death] necrosis (course) Necrosis (course) is a subtype of cell death (course). The totality of all processes through which necrosis is realized. Necrosis is a type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues. PMID:18846107 PMID:20823910 under construction DNA damage (severe) [necrosis] cell rupture [Cell death] increasing drug metabolite [cell death] metabolic dysfunction [Cell death] inflammatory response [Cell death] abnormality of membrane (severe) [Cell death] necrosis [Cell death] increasing cell volume [Necrosis] hypoxia [Cell death] electrophiles formation [cell death] binding to DNA by electrophiles [cell death]