has input has output has context has agent Phosphorylation of eIF2-alpha by PERK Phosphorylation of eIF2-alpha by PERK [ER stress] PMID:23334697 PMID:9930704 Phosphorylation of eIF2-alpha by PERK is a subtype of eIF2a phosphorylation: A process that The process of introducing a phosphate group into eIF2a by PERK. This entity is a specific course-dependent process. This process can constitute the course of ER stress. Reactome:R-HSA-381111 The C-terminal domain of PERK (EIF2AK3) has kinase activity when PERK homodimerizes. PERK kinase specifically phosphorylates Ser52 of eIF2-alpha, causing an arrest in translation. The result is that translation of ER-targeted proteins is halted on ribosomes in the vicinity of activated PERK. The general arrest of translation results in the loss of short-lived proteins such as Cyclin D1, causing an arrest of the cell cycle in G1. P-EIF2A (canonical)[ER stress] PERK (canonical)[ER stress] EIF2A (canonical)[ER stress] endoplasmic reticulum stress [toxic course] ER stress dependent process (molecular level)