has related human gene CYP7A1 cholestasis dependent molecule (canonical) Cyp7a1 (mol) CYP7A1 (canonical)[Cholestasis] Bile acids repress the transcription of cytochrome P450 7A1 (CYP7A1), which catalyzes the rate-limiting step in bile acid biosynthesis. FXR induces expression of SHP-1, a member of the nuclear receptor family that lacks a DNA-binding domain. SHP-1 represses expression of CYP7A1 by inhibiting the activity of liver receptor homolog 1 (LRH-1). RXR heterodimers regulates absorption and ABC1-mediated efflux of cholesterol. Oxysterol receptors (LXRs) and the bile acid receptor (FXR) are the RXR heterodimer by regulating expression of the reverse cholesterol transporter, ABC1, and the enzyme of bile acid synthesis, CYP7A1, respectively. http://omim.org/entry/118455 NCBI-Human-GeneID:1581 NCBI-Rat-GeneID:25428 NCBI-Mouse-GeneID:13122