dysfunctioning of endosome to lysosome transport of low-density lipoprotein particle hypofunction of cholesterol transport hypofunction of endosome to lysosome transport of low-density lipoprotein particle Hypofunction of endosome to lysosome transport of low-density lipoprotein particle is a subtype of hypofunction of cholesterol transport: A process that performs a decreased or insufficient endosome to lysosome transport of low-density lipoprotein particle. decreasing endosome to lysosome transport of LDL