participates in has role relateds assay antioxidant autophagy [ER stress] cell survival [ER stress] in vivo assay ER stress dependent molecule (rat) Hmox1 (rat)[ER stress] Heme Oxygenase 1 [ER stress] PMID:12649161 http://omim.org/entry/141250 oxidative stress ->oxidized lipids production ->ER stress induction (PERK(->eIF2a), JNK)->activation of autophagy->HO-1activation->cell survival Oxidized lipids activate autophagy in a JNK-dependent manner by stimulating the endoplasmic reticulum stress response. HNE modification of ER proteins results in the activation of the adaptive arm of the unfolded protein response. This HNE-mediated response is characterized by the phosphorylation of PERK, eIF2α, and JNK, activation of autophagy, and the induction of HO-1. HNE-stimulated conversion of LC3 (an essential step in autophagosome formation and marker of autophagy) and HO-1 induction is shown to be mediated by ER stress via JNK activation. PMID:24024137 NCBI-Rat-GeneID:24451 JNK signaling (primitive) [ER stress] Hmox1 (mol)