relateds assay has related human gene family of FGF-21 FGF21 ER stress dependent molecule (human in vitro) in vitro assay (human) FGF21 (human)[ER stress] ER stress and PPARα activation contribute to carcinogenesis in a fatty liver. PMID:22009939 Hepatosteatosis in peroxisome deficient liver despite increased beta-oxidation capacity and impaired lipogenesis. Biochimie (2011) 93:1828–38. FGF21-FGFR1 coordinates phospholipid homeostasis, lipid droplet function and ER stress in obesity.Endocrinology. 2016 PMID:27690692 Fibroblast growth factor 21 (FGF21) is an endocrine growth factor, a regulator of fatty acids and glucose metabolism. Recently, it has been reported that FGF21 expression is regulated by activating transcription factor 4 (ATF4), a transcription factor activated by various stimuli such as endoplasmic reticulum (ER) stress. PMID:27010621 Endoplasmic reticulum stress induces up-regulation of hepatic beta-Klotho expression through ATF4 signaling pathway. PMID:25727012 PMID:17550777 PMID:22009939 PMID:25727012 PMID:27010621 PMID:27690692 NCBI-Human-GeneID:26291 FGF21 (mol)