has role relateds assay has related human gene apoptosis inducer in vitro assay CHAC1 ER stress dependent molecule (human in vitro) CHAC1 (human)[ER stress] PMID:19109178 PMID:23070364 PMID:25931127 This gene encodes a member of the gamma-glutamylcyclotransferase family of proteins. The encoded protein has been shown to promote neuronal differentiation by deglycination of the Notch receptor, which prevents receptor maturation and inhibits Notch signaling. This protein may also play a role in the unfolded protein response, and in regulation of glutathione levels and oxidative balance in the cell. Elevated expression of this gene may indicate increased risk of cancer recurrence among breast and ovarian cancer patients. [provided by RefSeq, Sep 2016] http://purl.obolibrary.org/obo/NCBIGene_79094 NCBI-Human-GeneID:79094 CHAC1 (mol)