has part has core process inflammatory cytokine gene expression [Lipidosis] insulin resistance [NASH] hyperfunction of fatty acid biosynthesis [Lipidosis] hypofunction of lipid degradation [Lipidosis] hyperfunction of lipid biosynthesis [Lipidosis] hyperfunction of lipid synthetic gene expression [Lipidosis] lipid homeostasis imbalance (severe) [Lipidosis] lipid metabolism imbalance (severe) [Lipidosis] positive regulation of mitochondrial membrane permeability [lipidosis] decreasing mitochondrial membrane potential [lipidosis] reactive oxygen species biosynthetic process [lipidosis] hyporfunction of alcohol metabolism [Lipidosis] USF1 activation [lipidosis] SREBP activation [lipidosis] malfunctioning of insulin signaling [lipidosis] LXRa activation [lipidosis] ChREBP activation [lipidosis] dysfunction of peroxisomal fatty acid beta-oxidation [NASH] non-alcoholic steatohepatitis (toxic course) NASH (toxic course) The totality of all processes through which non-alcoholic steatohepatitis (NASH) is realized. Dysfunction of mitochondrial fatty acid beta-oxidation (severe) [Lipidosis] PPAR alpha inactivation [Lipidosis] heme biosynthetic process [lipidosis] hypofunction of PPARa regulated gene expression [NASH] release of DNA from mitochondria [lipidosis] electrophiles formation [NASH] protein unfolding [lipidosis] dysfunction of fatty acid degradation [Lipidosis] lipid accumulation in hepatocyte (severe) [Lipidosis] positive regulation of autophagy [Lipidosis] increasing hepatocellular volume [Lipidosis] hyperfunction of glucose transport to liver [Lipidosis] hypofunction of triglyceride transport from hepatocyte to extrahepatic [Lipidosis] necrosis [Lipidosis] non-alcoholic fatty liver disease hypofunction of lipoprotein biosynthesis [Lipidosis] increasing demand for response to oxidative stress [Lipidosis] cellular membrane lipoperoxidation [Lipidosis] inflammatory response [Lipidosis] hepatic fibrosis [Lipidosis] inflammatory cell infiltration [Lipidosis] Increasing drug metabolite [lipidosis] Cytochrome P450 activation [NASH] overeating [NAFLD] increasing fatty acid synthesis substrate [lipidosis] converting to acetyl CoA [NAFLD] increasing amount of carbohydrate [NAFLD] increase in lipid inflow into hepatocyte [NAFLD] increaing in fatty acid inflow into hepatocyte [NAFLD] increasing volume of mitochondria [lipidosis]