pharmacological role Cationic Amphiphilic Drug role Arole played by the entity that has both hydrophobic and hydrophilic properties with a charged cationic amine group. CAD role PMID:9061852 CADs exhibit the property of lysosomotropism, the property of a molecule to specifically associate with lysosomes. In theory, CADs could enter the lysosome through endocytosis, autophagy, or a drug-specific transporter. However, passive diffusion has been invoked as the major mechanism whereby CADs accumulate within the lysosome . CADs bind directly to phospholipids to result in indigestible drug–lipid complexes, which accumulate and are stored in the form of lysosomal lamellar bodies. Production of lamellar bodies was associated with inhibition of phospholipase activity; either due to direct inhibition or interaction of CAD at the phospholipid bilayer of the lysosome.