has context has agent xenobiotic glucuronidation UGT1A1 (canonical)[Ground glass appearance] ground glass apperance [toxic corse] xenobiotic glucuronidation [Ground glass appearance] In the liver, bilirubin is conjugated with glucuronic acid by the enzyme glucuronyltransferase, making it soluble in water: the conjugated version is the main form of bilirubin present in the "direct" bilirubin fraction. Much of it goes into the bile and thus out into the small intestine. The modification of a xenobiotic substance by the conjugation of glucuronic acid. The resultant glucuronosides are often much more water-soluble than the xenobiotic precursor, enabling efficient excretion. This entity is a specific course-dependent process. This process can constitute the course of Ground glass appearance. UGT1A1 responsible for conjugating bilirubin is inducible by CAR activators such as phenobarbital and scoparone.