has part has result pulmonary infection [Niemann Pick Disease Type A] sphingomyelin accumulation in lysosome of nervous system [Niemann Pick Disease Type A (severe) ] severe sphingomyelin accumulation in lysosome [Niemann Pick Disease Type A/ B (severe)] severe sphingomyelin accumulation in lysosome [Niemann Pick Disease Type A] Sphingomyelin accumulation in lysosome is a subtype of sphingophospholipid accumulation in lysosome: A process that keeps sphingomyelin in the lysosome. This entity is a specific course-dependent process. This process can constitute the course of Niemann Pick Disease Type A. splenohepatomegaly [Niemann Pick Disease Type A]