has molecular reaction has result has context has agent Dissociation of PERK:BIP Heterodimer [ER stress translation attenuation] ER stress dependent process receiving abnormal protein signal by PERK [ER stress - refolding] Receiving abnormal protein signal by PERK is a subtype of receiving signal: A process that recognizes another object and changes into an abnormal protein (e.g., misfolded protein, etc.) signal by PERK. This process is dependent on the refolding and can constitute the course of ER stress via protein refolding. PERK signaling to eIF2a [ER stress - refolding] endoplasmic reticulum stress [toxic course] receiving abnormal protein signal by PERK [ER stress] PERK - signal sensor (canonical)[ER stress - Refolding]