has input has output has result has context has agent electrophiles formation glutathione depletion [toxic course] glutathione depletion dependent process NAPQI [Glutathione depletion] increasing demand for glutathione conjugation [Glutathione depletion] electrophiles formation [Glutathione depletion] A number of xenobiotics exert a toxic effect theough their metabolites. Electrophiles are molecules that contain an electron-deficient atom with a partial or full positive charge that can react by sharing electron pairs with electron rich atoms in nucleophiles. Electrophilic toxicants generally are detoxificated by conjugation of with the nucleophile, glutathione. This reaction can be facilitated by glutathione S-trasferases. Electrophiles formation is a subtype of biosynthetic process: A process that that generates electrophiles. Electrophile is a reagent that forms a bond to its reaction partner (the nucleophile) by accepting both bonding electrons from that reaction partner. This entity is a specific course-dependent process. This process can constitute the course of Glutathione depletion. PMID:21177773 Acetaminophen [Glutathione depletion] Keap1 modification by electrophiles [Glutathione depletion] autophagy dependent Keap1 catabolic process [Glutathione depletion] CYP2E1 (canonical)[Glutathione depletion] CYP3A4 (canonical)[Glutathione depletion] CYP1A2(canonical) [Glutathione depletion]