has part has core process toxic course mitochondrial respiratory chain abnormality [Mitochondrial disorder] mitochondrial dysfunction [Mitochondrial disorder] increasing demand for response to mitochondrial oxidative stress [Mitochondrial disorder] increasing volume of mitochondria [Mitochondrial disorder] mitochondrial damage [toxic course] The totality of all processes through which mitochondrial damage is realized. under construction ATP depletion [Mitochondrial disorder] negative regulation of respiratory electron transport chain [Mitochondrial disorder] reactive oxygen species biosynthetic process [Mitochondrial disorder] positive regulation of mitochondrial membrane permeability [Mitochondrial disorder] apoptotic process [Mitochondrial disorder] decreasing mitochondrial membrane potential [Mitochondrial disorder] malfunctioning of uncoupling [Mitochondrial disorder] negative regulation of mitochondrial gene expression [Mitochondrial disorder] lipid storage in liver [Mitochondrial disorder] hypofunction of mitochondrial fatty acid beta-oxidation [Mitochondrial disorder] changing iron ion concentration [Mitochondrial disorder] mitohagy [Mitochondrial disorder] leaking proton ion [Mitochondrial disorder] oxidative phosphorylation uncoupling [mitochondrial disorder] fatty acid strorage [Mitochondrial disorder] PPARalpha activation [Mitochondrial disorder] decreasing proton motive force [Mitochondrial disorder] hypofunction of ATP biosynthesis [Mitochondrial disorder] cell death [Mitochondrial disorder] glutathione depletion [Mitochondrial disorder] negative regulation of mitochondrial electron transport, NADH to ubiquinone [Mitochondrial disorder] negative regulation of mitochondrial electron transport, succinate to ubiquinone [Mitochondrial disorder] negative regulation of mitochondrial electron transport, ubiquinol to cytochrome c [Mitochondrial disorder] DNA damage [Mitochondrial disorder] negative regulation of heat generation [Mitochondrial disorder] negative regulation of oxidative phosphorylation [Mitochondrial disorder] malfunctioning of TCA cycle [Mitochondrial disorder] increasing acetyl CoA [Mitochondrial disorder] increasing uptake amount of mitochondrial proton ion [Mitochondrial disorder] positive regulation of oxidative phosphorylation uncoupling [Mitochondrial disorder] tumorigenesis [Mitochondrial disorder] Negative regulation of respiratory complex proteins synthesis cyclin B1-CDK1 complex inactivation [mitochondrial disorder] ACTA2 production [mitochondrial disorder] CCL2 production [mitochondrial disorder] COL1A1 production [mitochondrial disorder] negative regulation of cell cycle G2/M phase transition [mitochondrial disorder] GDF15 inactivation [mitochondrial disorder] JNK signaling (primitive) [mitochondrial disorder] NEAT1 inactivation [mitochondrial disorder] NfkB signaling (primitive) [Mitochondrial disorder] p38 signaling (primitive) [mitochondrial disorder] TLR9 signaling [Mitochondrial disorder] tumor necrosis factor production [mitochondrial disorder] alcohol intake [mitochondrial disorder] interleukin-6 production [mitochondrial disorder] binding to mtDNA by radicals [mitochondrial disorder]] increasing free radical [mitochondrial disorder] release of DNA from mitochondria [mitochondria disorder] decreasing mtDNA level [mitochondrial disorder] mitochondria fission [Mitochondrial disorder] mitochondrial DNA catabolic process [mitochondrial disorder] release of cytochrome c from mitochondria [mitochondrial disorder] metabolic dysfunction of precursor metabolites and energy generation [mitochondrial disorder] Negative regulation of respiratory complex IV proteins synthesis [mitochondrial disorder] monocyte migration [mitochondrial disorder] increasing uptake amount of mitochondrial calcium ion [Mitochondrial disorder] neutrophil migration [mitochondrial disorder] cytokine production involved in inflammatory response [mitochondrial disorder] inflammatory cytokine gene expression [mitochondrial disorder] Inflammatory response [mitochondrial disorder] cellular damage [mitochondrial disorder] Tumor-associated macrophage activation[Mitochondrial disorder] tumor-associated macrophage migration [mitochondrial disorder] lipoperoxidation [mitochondrial disorder] hepatic fibrosis [mitochondrial disorder] liver malfunction [mitochondrial disorder] carbon tetrachloride metabolic process [mitochondrial disorder] collagen deposition [mitochondrial disorder] IL6 signaling [Mitochondrial disorder] STAT3 activation[Mitochondrial disorder] increasing demand for response to ER stress [mitochondrial disorder] cardiolipin peroxidation [mitochondrial disorder] necrosis [mitochondrial disorder] cellular membrane lipoperoxidation [mitochondrial disorder] hepatic stellate cell activation [mitochondrial disorder] mitochondrial membrane morphology changes [mitochondrial disorder] IL-1beta production [mitochondrial disorder] Insulin resistance (process) [mitochondrial disorder] Calcium ion homeostasis imbalance [mitochondrial disorder] Hypofunction of sequestering of calcium ion in ER [mitochondrial disorder] mitochondria morphology change [mitochondrial disorder] redox changes [mitochondrial disorder] nagative regulation of mitophagy [mitochondrial disorder] mitochondrial fatty acid beta-oxidation [mitochondrial disorder] hyperfunction of CYP2E1 gene expression [mitochondrial disorder] hyperfunction of gluconeogenesis [mitochondrial disorder] Increasing damaged mitochondria [mitochondrial disorder] increasing CPT1 level [mitochondrial disorder] hypofunction of anti-oxidative stress[mitochondrial disorder] gluconeogenesis [mitochondrial disorder] lipid biosynthetic process [mitochondrial disorder] increasing demand for response to oxidative stress [mitochondrial disorder] ketone body biosynthetic process [mitochondrial disorder] Negative regulation of mitochondrial respiratory chain complex I subunit phosphorylation [mitochondrial disorder] cell cycle arrest [mitochondrial disorder] Increasing HMGB1 level [mitochondrial disorder] TLR4 signaling [mitochondrial disorder] Malfunctioning of insulin signaling [mitochondrial disorder] inflammasome activation [mitochondrial disorder] HIF1A activation [mitochondrial disorder] inducible nitric oxide synthase production [mitochondrial disorder] Hypofunction of PPARGC1A gene expression [mitochondrial disorder] increasing production amount of reactive aldehyde [mitochondrial disorder] Iron accumulation [mitochondrial disorder] negative regulation of AKT signaling [mitochondrial disorder] Negative regulation of ATP transport [mitochondrial disorder] C9ORF72 inactivation [mitochondrial disorder] positive regulation of autophagy [mitochondrial disorder] positive regulation of mitophagy [mitochondrial disorder] Dysregulation of mitochondrion organization Increasing mitochondrial membrane potential [mitochondrial disorder] CDK1 inactivation [mitochondrial disorder] FAS signaling [mitochondrial disorder] increasing FGF21 level [mitochondrial disorder] FOXO1 activation [mitochondrial disorder] Hypofunction of heme biosynthesis [mitochondrial disorder] Increasing production quantity of NO [mitochondrial disorder] increasing production quantity of RNS [mitochondrial disorder] NRF2 inactivation [mitochondrial disorder] negative regulation of antioxidant enzyme activation [mitochondrial disorder] hypofunction of lipid biosynthesis [mitochondrial disorder] PCK1 activation [mitochondrial disorder] negative regulation of gluconeogenesis [mitochondrial disorder] PKC activation [mitochondrial disorder] hypofunction of S-adenosylmethionine biosynthetic process [mitochondrial disorder] decreasing glutathione level [mitochondrial disorder] Hypofunction of TFAM gene expression [mitochondrial disorder] cytolysis [mitochondrial disorder] TNF signaling [mitochondrial disorder] decreasing adiponectin level [mitochondrial disorder] hypofunction of oxysterol biosynthesis [mitochondrial disorder] autophagy [mitochondrial disorder] Increasing glucagon level [mitochondrial disorder] glucose homeostasis imbalance [mitochondrial disorder] increasing glucose level [mitochondrial disorder] Decreasing glucose level [mitochondrial disorder] Increasing ketone body level [mitochondrial disorder] Increasing cholesterol level [mitochondrial disorder] Increasing triol level [mitochondrial disorder] diacylglycerol accumulation [mitochondrial disorder] ceramide accumulation [mitochondrial disorder] Increasing fructose level [mitochondrial disorder] Hypofunction of mitochondrial repair [mitochondrial disorder] Increasing uric acid level [mitochondrial disorder] macrophage migration [mitochondrial disorder] Disruption of ER-mitochondria contact sites [mitochondrial disorder] Negative regulation of glutathione transport into mitochondria [mitochondrial disorder] long-chain fatty acid import into mitochondria [mitochondrial disorder] Increase in mitochondrial calcium level [mitochondrial disorder] mitochondrial cholesterol storage [mitochondrial disorder] phospholipid peroxidation [mitochondrial disorder] increasing leptin level [mitochondrial disorder] release of inflammatory DAMPs [mitochondrial disorder] increasing blood glucose level [mitochondrial disorder] increasing lipid concentration [mitochondrial disorder] Increasing cholesterol concentration in blood [mitochondrial disorder] Increasing long-chain free fatty acid level [mitochondrial disorder] Increasing saturated fatty acid level [mitochondrial disorder] NDUFA12 inactivation [mitochondrial disorder] NDUFB6 inactivation [mitochondrial disorder] NDUFS2 inactivation [mitochondrial disorder] NDUFV1 inactivation [mitochondrial disorder] NDUFV3 inactovation [mitochondrial disorder]