uncoupling dependent molecule (rat in vivo) Ucp3 (rat)[Uncoupling] GENATLAS Biochemistry: uncoupling protein of inner mitochondrial membrane 3,with two forms,long and short missing C terminal 37 residues,dissipating the proton electrochemical gradient by uncoupling fuel oxidation from ADP-ATP conversion,highly expressed in skeletal muscle during development,regulated by nutritional factors,possible mediator of adaptive thermogenesis,involved in the variation of energy metabolism and obesity,regulated by PPARA and PPARG in mice,and dysregulated in states of insulin resistance,increased expression in function of obesity and in type 2 diabetes (NIDDM) UCP3 UniProtKB/Swiss-Prot Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance. UCP3_HUMAN,P55916 PMID:19710539 https://omim.org/entry/602044 NCBI-Human-GeneID:7352 NCBI-Rat-GeneID:25708 NCBI-Mouse-GeneID:22229 UCP3 (mol)