has participant mitochondrial disorder dependent process oxidative phosphorylation uncoupling [mitochondrial disorder] Enables the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis. This entity is a specific course-dependent process. This process can constitute the course of Mitochondrial disorder. PMID:21145849 PMID:25339807 oxidative phosphorylation uncoupling perhexiline [mitochondrial disorder] amiodarone [mitochondrial disorder]] alpidem [mitochondrial disorder] tamoxifen [mitochondrial disorder] buprenorphine [mitochondrial disorder] salicylic acid [mitochondrial disorder] diclofenac [mitochondrial disorder] nimesulide [mitochondrial disorder] ibuprofen [mitochondrial disorder] tacrine [mitochondrial disorder]