has part has attribute value has attribute balance state state of functional supply medium level functional demand state toxicological imbalance M=M (maintining homeostasis in the normal condition) In the imbalance model, the basic units are as follows: 1) a functioning process (supply) for biological defense and maintaining homeostasis; 2) a functional demand process (demand) as toxic activity; 3) balance/imbalance between toxic activity and defense processes; and 4) outcome from organelles, cells, or tissues to the organ exhibiting toxicity manifestations. The defense performance level and the functional demand level are moderate (M) under the normal condition and keeping the balance. power (attribute) toxicological imbalance