has component BIP-STRESS sensor complex (canonical)[ER stress] BIP-IRE1 complex (canonical)[ER stress] BIP-IRE1 complex is a subtype of molecular complex. This entity has sub-parts of molecules, BIP/GRP78 and IRE1 which has role of stress sensor. This entity is dependent on ER stress. GRP78 - stress sensor inhibitor (canonical)[ER stress - proteinrefolding [persist] -IRE1 pathway]